Increase of the plasma α-synuclein levels in patients with multiple system atrophy.
Identifieur interne : 000547 ( Main/Exploration ); précédent : 000546; suivant : 000548Increase of the plasma α-synuclein levels in patients with multiple system atrophy.
Auteurs : Zhan-Fang Sun [République populaire de Chine] ; Xiao-Shuang Xiang ; Zhao Chen ; Li Zhang ; Bei-Sha Tang ; Kun Xia ; Hong JiangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Brain (metabolism), Brain (pathology), Enzyme-Linked Immunosorbent Assay (methods), Female, Gene Expression (physiology), Humans, Inclusion Bodies (pathology), Male, Middle Aged, Multiple System Atrophy (blood), Multiple System Atrophy (genetics), alpha-Synuclein (blood), alpha-Synuclein (genetics).
- MESH :
- chemical , blood : alpha-Synuclein.
- blood : Multiple System Atrophy.
- genetics : Multiple System Atrophy, alpha-Synuclein.
- metabolism : Brain.
- methods : Enzyme-Linked Immunosorbent Assay.
- pathology : Brain, Inclusion Bodies.
- physiology : Gene Expression.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Multiple system atrophy, a sporadic neurodegenerative disease, is characterized by the presence of high numbers of glial cytoplasmic inclusions mainly formed by α-synuclein protein, which is encoded by the SNCA gene. To date, however, few studies have investigated the plasma α-synuclein levels in patients with multiple system atrophy. We studied plasma α-synuclein concentrations by using an enzyme-linked immunosorbent assay in 74 patients with multiple system atrophy and 90 healthy controls. The plasma α-synuclein levels were significantly elevated in patients who had multiple system atrophy compared with the control group (P = 0.000). In a subgroup of 48 patients who had probable multiple system atrophy, there was a weakly negative correlation between plasma α-synuclein levels and subscores on Unified Multiple System Atrophy Rating Scale item VI (r(s) = -0.307; P = 0.034). Plasma α-synuclein levels were elevated in patients with multiple system atrophy, and these levels may be decreased with the development of disease.
DOI: 10.1002/mds.25688
PubMed: 24115000
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000751
- to stream PubMed, to step Curation: 000751
- to stream PubMed, to step Checkpoint: 000556
- to stream Ncbi, to step Merge: 003D46
- to stream Ncbi, to step Curation: 003D46
- to stream Ncbi, to step Checkpoint: 003D46
- to stream Main, to step Merge: 000547
- to stream Main, to step Curation: 000547
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increase of the plasma α-synuclein levels in patients with multiple system atrophy.</title><author><name sortKey="Sun, Zhan Fang" sort="Sun, Zhan Fang" uniqKey="Sun Z" first="Zhan-Fang" last="Sun">Zhan-Fang Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Xiao Shuang" sort="Xiang, Xiao Shuang" uniqKey="Xiang X" first="Xiao-Shuang" last="Xiang">Xiao-Shuang Xiang</name></author><author><name sortKey="Chen, Zhao" sort="Chen, Zhao" uniqKey="Chen Z" first="Zhao" last="Chen">Zhao Chen</name></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name></author><author><name sortKey="Tang, Bei Sha" sort="Tang, Bei Sha" uniqKey="Tang B" first="Bei-Sha" last="Tang">Bei-Sha Tang</name></author><author><name sortKey="Xia, Kun" sort="Xia, Kun" uniqKey="Xia K" first="Kun" last="Xia">Kun Xia</name></author><author><name sortKey="Jiang, Hong" sort="Jiang, Hong" uniqKey="Jiang H" first="Hong" last="Jiang">Hong Jiang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24115000</idno><idno type="pmid">24115000</idno><idno type="doi">10.1002/mds.25688</idno><idno type="wicri:Area/PubMed/Corpus">000751</idno><idno type="wicri:Area/PubMed/Curation">000751</idno><idno type="wicri:Area/PubMed/Checkpoint">000556</idno><idno type="wicri:Area/Ncbi/Merge">003D46</idno><idno type="wicri:Area/Ncbi/Curation">003D46</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D46</idno><idno type="wicri:Area/Main/Merge">000547</idno><idno type="wicri:Area/Main/Curation">000547</idno><idno type="wicri:Area/Main/Exploration">000547</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increase of the plasma α-synuclein levels in patients with multiple system atrophy.</title><author><name sortKey="Sun, Zhan Fang" sort="Sun, Zhan Fang" uniqKey="Sun Z" first="Zhan-Fang" last="Sun">Zhan-Fang Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Xiao Shuang" sort="Xiang, Xiao Shuang" uniqKey="Xiang X" first="Xiao-Shuang" last="Xiang">Xiao-Shuang Xiang</name></author><author><name sortKey="Chen, Zhao" sort="Chen, Zhao" uniqKey="Chen Z" first="Zhao" last="Chen">Zhao Chen</name></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name></author><author><name sortKey="Tang, Bei Sha" sort="Tang, Bei Sha" uniqKey="Tang B" first="Bei-Sha" last="Tang">Bei-Sha Tang</name></author><author><name sortKey="Xia, Kun" sort="Xia, Kun" uniqKey="Xia K" first="Kun" last="Xia">Kun Xia</name></author><author><name sortKey="Jiang, Hong" sort="Jiang, Hong" uniqKey="Jiang H" first="Hong" last="Jiang">Hong Jiang</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Female</term><term>Gene Expression (physiology)</term><term>Humans</term><term>Inclusion Bodies (pathology)</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (blood)</term><term>Multiple System Atrophy (genetics)</term><term>alpha-Synuclein (blood)</term><term>alpha-Synuclein (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Multiple System Atrophy</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Inclusion Bodies</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy, a sporadic neurodegenerative disease, is characterized by the presence of high numbers of glial cytoplasmic inclusions mainly formed by α-synuclein protein, which is encoded by the SNCA gene. To date, however, few studies have investigated the plasma α-synuclein levels in patients with multiple system atrophy. We studied plasma α-synuclein concentrations by using an enzyme-linked immunosorbent assay in 74 patients with multiple system atrophy and 90 healthy controls. The plasma α-synuclein levels were significantly elevated in patients who had multiple system atrophy compared with the control group (P = 0.000). In a subgroup of 48 patients who had probable multiple system atrophy, there was a weakly negative correlation between plasma α-synuclein levels and subscores on Unified Multiple System Atrophy Rating Scale item VI (r(s) = -0.307; P = 0.034). Plasma α-synuclein levels were elevated in patients with multiple system atrophy, and these levels may be decreased with the development of disease.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Zhao" sort="Chen, Zhao" uniqKey="Chen Z" first="Zhao" last="Chen">Zhao Chen</name><name sortKey="Jiang, Hong" sort="Jiang, Hong" uniqKey="Jiang H" first="Hong" last="Jiang">Hong Jiang</name><name sortKey="Tang, Bei Sha" sort="Tang, Bei Sha" uniqKey="Tang B" first="Bei-Sha" last="Tang">Bei-Sha Tang</name><name sortKey="Xia, Kun" sort="Xia, Kun" uniqKey="Xia K" first="Kun" last="Xia">Kun Xia</name><name sortKey="Xiang, Xiao Shuang" sort="Xiang, Xiao Shuang" uniqKey="Xiang X" first="Xiao-Shuang" last="Xiang">Xiao-Shuang Xiang</name><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Sun, Zhan Fang" sort="Sun, Zhan Fang" uniqKey="Sun Z" first="Zhan-Fang" last="Sun">Zhan-Fang Sun</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000547 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000547 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24115000
|texte= Increase of the plasma α-synuclein levels in patients with multiple system atrophy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24115000" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |